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USDAR Bio

Study Info

Started In 2021

Sites 5

Enrolled 67


USDAR BIO: Premise

USDAR Consortium sites provide the foundation for creating the largest drug allergy biorepository in the United States. Allergy specialists typically rule out or confirm drug allergies by using tests such as skin tests, patch tests, and drug challenge tests. However, knowledge of the underlying biological mechanisms of drug allergy and risk factors for drug allergy is limited. The USDAR Biorepository invites patients with confirmed drug allergies to enroll. Their samples will provide insight into the biological mechanisms and associations with true drug allergy. These samples, combined with medical and drug allergy history, will provide a holistic understanding of their drug allergy and advance drug allergy knowledge and possible biological mechanisms.

Study Goals:

Understand drug allergy

Capture individuals truly allergic to medications

To assess immunophenotypes of drug allergy

We will assess immune cell activation patterns and biomarkers to discover more about the science of drug allergy

Our Process

01

Patient Identification

Patients with acute drug reactions or those who test positive with drug allergy tests are eligible for USDAR BIO

02

Sample Collection

We collect clinical data, perform surveys, and collect samples from blood and sometimes urine and saliva from participants who consent and enroll in USDAR BIO

03

Analysis

Samples are analyzed to discover drug allergy mechanisms and associations

Participating Sites

Mayo Clinic Florida
Mayo Clinic Rochester
Mayo Clinic Arizona
Massachusetts General Hospital
Vanderbilt University

Team Members

Mayo Clinic Florida
PI, Allergy
Kimberly Blumenthal, MD, MSc
Massachusetts General Hospital
John Accarino, MD
Mayo Clinic Rochester
Site PI, Emergency Department
Ronna Campell, MD, PhD
Mayo Clinic Rochester
Site Investigator, Allergy
Elina Jerschow, MD
Mayo Clinic Arizona
Site PI
Alexei Gonzalez Estrada, MD
Massachusetts General Hospital
Site PI
Michelle Conroy, MD
Vanderbilt University
Site PI
Elizabeth Phillips, MD
Mayo Clinic Florida
Site Investigator
Keith Sacco